From the Department of Biochemistry, McGill University, Montreal.
Received for publication April 9th, 1936.In conditions of intoxication by drugs, some organs react more readily than others. The thymus, the adrenal and the liver seem to be particularly sensitive. Diseases or experimentally-produced lesions of the adrenal or of the liver decrease the resistance of the organism to numerous toxic substances.
These findings made it very likely that the thymus, the adrenal and the liver play an important role in the defense reaction of the organism against drugs and traumatic injuries. In the present communication experiments are described which were designed to clarify some of the inter-relations which exist between these three organs after traumatic injuries and during various intoxications.